Isolated limb perfusion

Isolated limb perfusion (ILP) is a surgical procedure used primarily to treat melanoma and sarcoma located in an arm or leg. The procedure involves the isolation of the blood flow from the affected limb from the rest of the body's circulation, allowing for the delivery of high doses of chemotherapy or radiation directly to the tumor.

Procedure[edit | edit source]

The ILP procedure begins with the surgical isolation of the blood vessels supplying the affected limb. A tourniquet is applied to the limb to prevent blood flow to the rest of the body, and the blood in the limb is replaced with a solution containing the chemotherapy drug or radiation. The drug or radiation is then circulated through the limb for a set period of time, typically 60 to 90 minutes. After the treatment, the limb is flushed to remove any remaining drug or radiation before the tourniquet is removed and blood flow is restored.

Applications[edit | edit source]

ILP is most commonly used to treat melanoma and sarcoma located in an arm or leg. It may also be used to treat other types of cancer, such as carcinoma or lymphoma, if they are located in a limb. In some cases, ILP may be used to treat non-cancerous conditions, such as vascular disease or infection.

Risks and Complications[edit | edit source]

As with any surgical procedure, ILP carries some risks. These may include infection, bleeding, and nerve damage. There is also a risk of complications related to the chemotherapy or radiation, such as nausea, vomiting, and hair loss. In rare cases, the procedure may result in the need for amputation of the limb.

See Also[edit | edit source]

Isolated limb perfusion Resources
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