Clofarabine
(Redirected from Ivozall)
Clofarabine[edit | edit source]
Clofarabine is a purine nucleoside antimetabolite used in the treatment of certain types of cancer, particularly acute lymphoblastic leukemia (ALL) in pediatric patients. It is a second-generation nucleoside analog designed to overcome the limitations of earlier drugs such as cladribine and fludarabine.
Mechanism of Action[edit | edit source]
Clofarabine works by inhibiting DNA synthesis in rapidly dividing cells. It is phosphorylated intracellularly to its active triphosphate form, which then competes with deoxyadenosine triphosphate (dATP) for incorporation into DNA. This incorporation leads to chain termination and apoptosis of the cancer cells. Additionally, clofarabine inhibits ribonucleotide reductase, further depleting the pool of deoxynucleotides necessary for DNA synthesis.
Clinical Use[edit | edit source]
Clofarabine is primarily used in the treatment of pediatric patients with relapsed or refractory acute lymphoblastic leukemia. It is administered intravenously and is often used in combination with other chemotherapeutic agents. The drug has shown efficacy in inducing remission in patients who have not responded to other treatments.
Side Effects[edit | edit source]
Common side effects of clofarabine include myelosuppression, which can lead to neutropenia, anemia, and thrombocytopenia. Other side effects may include nausea, vomiting, diarrhea, and hepatotoxicity. Due to its immunosuppressive effects, patients receiving clofarabine are at increased risk of infections.
Pharmacokinetics[edit | edit source]
Clofarabine is rapidly absorbed and distributed throughout the body after intravenous administration. It is metabolized in the liver and excreted primarily in the urine. The drug has a half-life of approximately 5 hours, allowing for daily dosing during treatment cycles.
Development and Approval[edit | edit source]
Clofarabine was developed to improve upon the efficacy and safety profile of earlier nucleoside analogs. It was approved by the Food and Drug Administration (FDA) in 2004 for the treatment of pediatric acute lymphoblastic leukemia. Since its approval, clofarabine has been studied in various clinical trials to explore its potential use in other hematologic malignancies and solid tumors.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Deepika vegiraju, Prab R. Tumpati, MD
