KIF23

KIF23 is a protein that in humans is encoded by the KIF23 gene. It is a member of the kinesin-like protein family and plays a critical role in mitosis, particularly in the formation of the mitotic spindle apparatus, which is essential for proper cell division. KIF23 is involved in the separation of chromosomes during cell division, making it a key player in maintaining genomic stability and proper cell proliferation.

Function

KIF23 is a motor protein that moves along microtubules, converting chemical energy into mechanical work. This action is crucial during mitosis, where KIF23 helps to organize and segregate chromosomes by interacting with other proteins and structures within the cell. Specifically, it is part of the central spindle and midbody, playing a significant role in cytokinesis, the final separation of the two daughter cells.

Clinical Significance

Alterations in the expression or function of KIF23 have been implicated in various cancers. Overexpression of KIF23 has been observed in several types of tumors, suggesting a potential role in tumorigenesis and cancer progression. Due to its involvement in cell division, KIF23 is also being explored as a target for cancer therapy, with the idea that inhibiting its function could disrupt the proliferation of cancer cells.

Research

Research on KIF23 spans from understanding its basic biological functions to exploring its potential as a therapeutic target. Studies have used a variety of models, including yeast, Drosophila, and mammalian cells, to elucidate the mechanisms by which KIF23 contributes to mitosis and cell division. Additionally, efforts are being made to develop inhibitors that can specifically target KIF23, with the aim of providing new treatments for cancers characterized by its overexpression.

See Also

• Kinesin
• Mitosis
• Cell division
• Cancer therapy