KLRC4

Ideogram human chromosome 12

KLRC4

KLRC4 is a gene that encodes a protein known as killer cell lectin-like receptor subfamily C, member 4. This gene is located on chromosome 12 in humans. The KLRC4 protein is a type II transmembrane receptor that is primarily expressed on natural killer (NK) cells and some T cells.

Function

The KLRC4 protein is a member of the C-type lectin-like receptor family and plays a role in the regulation of NK cell function. It interacts with specific ligands to modulate the activity of NK cells in the immune response against infected or abnormal cells. The exact mechanisms by which KLRC4 functions are still being studied.

Clinical Significance

Mutations or dysregulation of the KLRC4 gene have been associated with certain diseases and conditions, including autoimmune disorders and cancer. Understanding the role of KLRC4 in the immune response may provide insights into potential therapeutic targets for these conditions.

Research

Research on KLRC4 is ongoing, with studies focusing on its role in immune surveillance, tumor immunity, and autoimmune diseases. By elucidating the molecular pathways involving KLRC4, researchers aim to develop novel treatment strategies for various immune-related disorders.

See also

• Natural killer cell
• Immune response
• C-type lectin-like receptor