KRT80

KRT80 also known as Keratin 80 is a type of keratin protein that is encoded in humans by the KRT80 gene. It is a member of the keratin family, which is a group of fibrous structural proteins that form the main component of the epithelial cells, which are cells that line the surfaces of the body.

Structure[edit | edit source]

KRT80 is a type I keratin, which means it is an acidic protein. It is characterized by its unique structure, which consists of a central alpha-helix domain flanked by non-helical head and tail domains. The alpha-helix domain is responsible for the coiled-coil structure that is characteristic of keratins.

Function[edit | edit source]

KRT80 plays a crucial role in maintaining the structural integrity of epithelial cells. It provides mechanical support to the cells, which is particularly important in tissues that are subject to constant physical stress, such as the skin, hair, and nails. In addition to its structural role, KRT80 is also involved in several cellular processes, including cell growth, differentiation, and migration.

Clinical significance[edit | edit source]

Mutations in the KRT80 gene have been associated with a variety of human diseases, including ichthyosis, a group of skin disorders characterized by dry, scaly skin. In particular, a specific mutation in the KRT80 gene has been linked to a rare form of ichthyosis known as ichthyosis hystrix.

Research[edit | edit source]

Research on KRT80 is ongoing, with scientists seeking to better understand its role in health and disease. This includes studying the effects of KRT80 mutations on cell function, as well as exploring potential therapeutic strategies for diseases associated with KRT80 mutations.

File:Keratin 80.jpg

Keratin 80 protein structure