Keratin 10
Keratin 10 (also known as KRT10) is a type of keratin protein that is primarily found in the upper layer of the epidermis. It is encoded by the KRT10 gene in humans.
Structure[edit | edit source]
Keratin 10 is a type I cytokeratin, one of the two types of keratin proteins. It is a fibrous protein that forms the intermediate filaments in epithelial cells. The structure of keratin 10 is characterized by a central alpha-helical rod domain that is flanked by non-helical head (N-terminal) and tail (C-terminal) domains.
Function[edit | edit source]
Keratin 10 plays a crucial role in maintaining the structural integrity of the epidermis. It contributes to the formation of the cornified envelope, a layer of dead skin cells that serves as a barrier to protect the body from environmental damage and water loss.
Clinical significance[edit | edit source]
Mutations in the KRT10 gene can lead to various skin disorders. For instance, Epidermolytic hyperkeratosis, a rare skin disorder characterized by blistering and thickening of the skin, is often caused by mutations in the KRT10 gene.
See also[edit | edit source]
References[edit | edit source]
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