Keratin 8

Keratin 8 (also known as KRT8) is a type of keratin protein that is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding this protein are part of the keratin gene family.

Structure

Keratin 8 is a type of intermediate filament protein, which are crucial components of the cytoskeleton that provide mechanical support for cells. Like all keratins, Keratin 8 is characterized by a central alpha-helical rod domain that is flanked by non-helical head (N-terminal) and tail (C-terminal) domains.

Function

Keratin 8 plays a vital role in maintaining the structural integrity of epithelial cells. It helps to protect epithelial tissues from stress and is involved in the organization and stabilization of the cytoskeleton. In addition, Keratin 8 is involved in the process of cell proliferation, cell differentiation, and wound healing.

Clinical significance

Mutations in the KRT8 gene have been associated with certain types of liver disease, including cirrhosis and cryptogenic liver disease. Additionally, abnormal expression of Keratin 8 has been observed in various types of cancer, including breast cancer, colorectal cancer, and pancreatic cancer, suggesting a potential role in tumorigenesis.

See also

• Keratin
• Keratin 18
• Epithelium
• Cytoskeleton