Kethoxal
Kethoxal (3-ethoxy-1,1-dihydroxy-2-butanone) is an organic compound that has antiviral and anaplasmosis properties.[1][2] It is also forms a stable covalent adduct with guanine, which makes it useful for nucleic acid structure determination.[3]
Nucleic acid binding[edit | edit source]
Kethoxal, as with other 1,2-dicarbonyl compounds,[4] reacts with nucleic acids. It has high specificity for guanine it over other ribonucleotides. In whole RNA, it reacts preferentially with guanine residues that are not involved in hydrogen-bonding.[5][6] It can thus be used to probe the interactions involved with the secondary structure and other binding interactions of RNA[7] and help with nucleic acid sequence analysis. The binding is reversible, which allows the kethoxal to be removed and the original RNA recovered.
References[edit | edit source]
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