Kinesin family member 11

Kinesin Family Member 11 (KIF11), also known as Eg5, is a motor protein that plays a crucial role in mitosis, the process of cell division. KIF11 belongs to the kinesin superfamily of proteins, which are known for their ability to move along microtubule tracks, transporting cellular cargo and facilitating various cellular processes. KIF11 is specifically involved in the formation and function of the mitotic spindle, an essential structure for the segregation of chromosomes during cell division.

Function

KIF11 functions as a plus-end-directed motor enzyme, meaning it moves towards the plus end of microtubules. It is a tetrameric protein that uses energy derived from ATP hydrolysis to move along microtubules and generate force. During mitosis, KIF11 is critical for the separation of centrosomes and the bipolar organization of the mitotic spindle. This organization is essential for the equal segregation of chromosomes into the two daughter cells. By controlling the dynamics of microtubules, KIF11 ensures that the genetic material is accurately divided, playing a vital role in cell proliferation and the maintenance of genomic stability.

Clinical Significance

Alterations in KIF11 function have been implicated in various human diseases. Overexpression of KIF11 has been observed in several types of cancer, including breast, prostate, and lung cancers, suggesting a role in tumorigenesis. Due to its essential role in cell division, KIF11 is a target for cancer therapeutics. Inhibitors of KIF11, such as monastrol, have been explored as potential anticancer agents. These inhibitors can disrupt mitotic spindle formation, leading to cell cycle arrest and apoptosis in cancer cells.

In addition to its implications in cancer, mutations in the KIF11 gene have been associated with genetic disorders such as microcephaly and lymphedema. These conditions highlight the importance of KIF11 in normal cell division and development.

Research

Research on KIF11 continues to uncover its complex role in cell division and its potential as a therapeutic target. Studies are focused on understanding the precise mechanisms by which KIF11 regulates mitotic spindle dynamics and identifying novel inhibitors that can selectively target KIF11 in cancer cells. The development of KIF11 inhibitors holds promise for the treatment of cancers with minimal side effects on normal cells.

See Also

• Mitosis
• Microtubule
• Cell division
• Cancer
• Protein kinase

References

Kinesin family member 11 Resources
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