Kurloff cells

Kurloff cells are a type of leukocyte or white blood cell, unique to guinea pigs and some other species. They are characterized by the presence of a large, single inclusion body within the cell.

History

Kurloff cells were first described by Paul Kurloff in 1924. He observed these cells in the blood of pregnant and non-pregnant female guinea pigs, and in the blood of male guinea pigs after hormone treatment.

Structure and Function

Kurloff cells are large, round cells with a single, large inclusion body. The inclusion body is made up of a protein called Kurloff body protein, which is thought to be involved in the immune response. Kurloff cells are believed to play a role in the immune response, particularly in the defense against viral infections and cancer.

Clinical Significance

The number of Kurloff cells in the blood can increase in response to certain conditions, such as pregnancy, hormone treatment, and certain diseases. An increased number of Kurloff cells can be a sign of an active immune response. However, the exact role of Kurloff cells in human disease is still not fully understood.

Research

Research into Kurloff cells is ongoing, with scientists hoping to better understand their role in the immune response and their potential use in the treatment of diseases.

See Also

• Leukocyte
• Inclusion body
• Immune response