L-α-Aminoadipate
L-α-Aminoadipate is an amino acid that is used in the biosynthesis of lysine, an essential amino acid. It is a non-proteinogenic amino acid, meaning it is not used in the construction of proteins. L-α-Aminoadipate is also known as α-aminoadipic acid or 2-aminoadipic acid.
Structure and Properties[edit]
L-α-Aminoadipate has a linear structure with a carboxyl group at one end and an amino group at the other. It is a diamino acid, meaning it contains two amino groups. The molecule is chiral, and the L-isomer is the one that is biologically active.
The molecular formula of L-α-Aminoadipate is C6H11NO4, and its molecular weight is 161.16 g/mol. It is a white, crystalline solid that is soluble in water.
Biosynthesis[edit]
In the biosynthesis of lysine, L-α-Aminoadipate is synthesized from homocitrate through several enzymatic steps. The enzymes involved in this process include aminoadipate aminotransferase, aminoadipate reductase, and saccharopine dehydrogenase.
Biological Role[edit]
In addition to its role in lysine biosynthesis, L-α-Aminoadipate has been found to have other biological roles. It is a neurotransmitter in the central nervous system, and it has been implicated in several neurological disorders, including epilepsy and Alzheimer's disease.
See Also[edit]
References[edit]
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