L-692,585

L-692,585 is a synthetic compound that acts as a potent and selective agonist of the growth hormone secretagogue receptor (GHS-R). It is primarily used in scientific research to study the regulation of growth hormone (GH) secretion and its physiological effects.

Chemical Structure and Properties

L-692,585 is a non-peptide compound with a complex chemical structure. It is characterized by its ability to mimic the action of ghrelin, the endogenous ligand for the GHS-R, thereby stimulating the release of growth hormone from the pituitary gland.

Mechanism of Action

L-692,585 binds to the GHS-R, which is a G-protein coupled receptor (GPCR) located in the pituitary gland and hypothalamus. Upon binding, it activates intracellular signaling pathways that lead to the secretion of growth hormone. This process involves the activation of the adenylate cyclase pathway and the subsequent increase in cyclic AMP (cAMP) levels, which ultimately results in the release of GH into the bloodstream.

Pharmacological Effects

The primary effect of L-692,585 is the stimulation of growth hormone release. This can lead to various physiological effects, including increased muscle mass, reduced body fat, and improved metabolic function. These effects make it a valuable tool in research focused on growth disorders, metabolic diseases, and aging.

Research Applications

L-692,585 is used extensively in preclinical studies to explore the role of growth hormone in various physiological and pathological conditions. It helps in understanding the potential therapeutic applications of GHS-R agonists in treating conditions such as growth hormone deficiency, cachexia, and sarcopenia.

Safety and Toxicology

As a research compound, L-692,585 is not approved for human use. Studies in animal models have shown that it is generally well-tolerated, but detailed toxicological profiles are necessary to fully understand its safety.

Also see

• Growth hormone secretagogue receptor
• Ghrelin
• Growth hormone
• Endocrinology