L-741,671
Overview[edit | edit source]
L-741,671 is a chemical compound that acts as a selective antagonist for the dopamine receptor D2. It is primarily used in scientific research to study the role of D2 receptors in various neurological and psychiatric conditions. L-741,671 is known for its high affinity and selectivity towards the D2 receptor, making it a valuable tool in neuropharmacology.
Chemical Properties[edit | edit source]
L-741,671 is classified as a benzamide derivative. Its chemical structure allows it to bind selectively to the D2 receptor, inhibiting its activity. The compound's molecular formula is C19H18Cl2N2O, and it has a molecular weight of 361.27 g/mol.
Mechanism of Action[edit | edit source]
L-741,671 functions by competitively binding to the dopamine D2 receptors, which are G protein-coupled receptors located in the central nervous system. By blocking these receptors, L-741,671 inhibits the action of dopamine, a neurotransmitter involved in regulating mood, reward, and motor control. This antagonistic action is useful in exploring the pathophysiology of disorders such as schizophrenia, Parkinson's disease, and bipolar disorder.
Research Applications[edit | edit source]
L-741,671 is extensively used in preclinical studies to:
- Investigate the role of D2 receptors in dopaminergic pathways.
- Explore the effects of D2 receptor antagonism in animal models of psychiatric and neurological disorders.
- Study the pharmacokinetics and pharmacodynamics of potential therapeutic agents targeting the D2 receptor.
Pharmacological Effects[edit | edit source]
In animal studies, L-741,671 has been shown to:
- Reduce hyperlocomotion induced by psychostimulants, indicating its potential antipsychotic properties.
- Modulate reward-related behaviors, providing insights into addiction mechanisms.
- Affect motor control, which is relevant for understanding movement disorders.
Safety and Toxicology[edit | edit source]
As with many research chemicals, the safety profile of L-741,671 in humans is not well-established. It is primarily used in controlled laboratory settings. Researchers handling L-741,671 should follow standard safety protocols to minimize exposure and potential risks.
Also see[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
