LDL-receptor-related protein-associated protein

LDL-receptor-related protein-associated protein (also known as LRPAP1 or RAP) is a protein that in humans is encoded by the LRPAP1 gene. It is a molecular chaperone protein that interacts with low density lipoprotein receptor-related protein 1 (LRP1) and other members of the LDL receptor family.

Function

LRPAP1 is a chaperone protein that regulates the folding and transport of low density lipoprotein receptor-related protein 1 (LRP1) and other members of the LDL receptor family. It binds to the alpha-2-macroglobulin receptor (LRP1) and may be involved in the pathogenesis of Alzheimer's disease and other related dementias.

Clinical significance

Mutations in the LRPAP1 gene have been associated with high myopia, a condition characterized by a refractive error of the eye. In addition, LRPAP1 has been implicated in the pathogenesis of Alzheimer's disease and other related dementias.

See also

• Low density lipoprotein receptor
• Alzheimer's disease
• Myopia

References

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