LG120907
LG120907 is a research chemical that is primarily used in scientific studies. It is a non-peptide antagonist of the neurokinin 1 receptor (NK1R).
Chemistry[edit | edit source]
LG120907 is a non-peptide molecule, which means it does not contain any amino acid sequences. This differentiates it from peptide antagonists, which are composed of amino acids. The chemical structure of LG120907 allows it to bind to the NK1R and inhibit its function.
Pharmacology[edit | edit source]
As an antagonist of the NK1R, LG120907 has the ability to block the actions of substance P, a neuropeptide that acts as a neurotransmitter and neuromodulator. Substance P is known to play a role in pain perception, and the NK1R is thought to mediate its effects. By blocking the NK1R, LG120907 can potentially modulate pain perception.
Research Use[edit | edit source]
LG120907 is primarily used in research settings. It is often used in studies investigating the role of the NK1R and substance P in various physiological processes, including pain perception, inflammation, and mood regulation.
Potential Therapeutic Applications[edit | edit source]
While LG120907 is not currently used in clinical practice, research suggests that it may have potential therapeutic applications. For example, it could potentially be used to develop new treatments for conditions associated with abnormal NK1R activity, such as chronic pain, depression, and anxiety disorders.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD