LGP2
LGP2 (Laboratory of Genetics and Physiology 2) is a protein that in humans is encoded by the DHX58 gene. It is a part of the RIG-I-like receptor (RLR) signaling pathway, which is a crucial component of the innate immune response to viral infections.
Function[edit | edit source]
LGP2 is a member of the DExD/H box family of RNA helicases. It acts as a negative regulator of the RLR pathway by preventing the interaction of MAVS (Mitochondrial Antiviral-Signaling protein) with RIG-I and MDA5, two other key proteins in the pathway. This regulation is essential for preventing excessive immune responses that could lead to harmful inflammation.
Clinical significance[edit | edit source]
Alterations in the function of LGP2 have been associated with a variety of diseases. For example, mutations in the DHX58 gene have been linked to increased susceptibility to viral infections. Additionally, dysregulation of the RLR pathway, in which LGP2 plays a key role, has been implicated in autoimmune diseases such as Systemic lupus erythematosus and Rheumatoid arthritis.
See also[edit | edit source]
- RIG-I-like receptor
- Innate immune response
- RNA helicase
- MAVS
- Systemic lupus erythematosus
- Rheumatoid arthritis
References[edit | edit source]
External links[edit | edit source]
LGP2 Resources | ||
---|---|---|
|
|
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD