LGP2
LGP2 (Laboratory of Genetics and Physiology 2) is a protein that in humans is encoded by the DHX58 gene. It is a part of the RIG-I-like receptor (RLR) signaling pathway, which is a crucial component of the innate immune response to viral infections.
Function[edit | edit source]
LGP2 is a member of the DExD/H box family of RNA helicases. It acts as a negative regulator of the RLR pathway by preventing the interaction of MAVS (Mitochondrial Antiviral-Signaling protein) with RIG-I and MDA5, two other key proteins in the pathway. This regulation is essential for preventing excessive immune responses that could lead to harmful inflammation.
Clinical significance[edit | edit source]
Alterations in the function of LGP2 have been associated with a variety of diseases. For example, mutations in the DHX58 gene have been linked to increased susceptibility to viral infections. Additionally, dysregulation of the RLR pathway, in which LGP2 plays a key role, has been implicated in autoimmune diseases such as Systemic lupus erythematosus and Rheumatoid arthritis.
See also[edit | edit source]
- RIG-I-like receptor
- Innate immune response
- RNA helicase
- MAVS
- Systemic lupus erythematosus
- Rheumatoid arthritis
References[edit | edit source]
External links[edit | edit source]
LGP2 Resources | |
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Contributors: Prab R. Tumpati, MD