LGR5

LGR5 or Leucine-rich repeat-containing G-protein coupled receptor 5 is a protein that in humans is encoded by the LGR5 gene. It is a member of the G protein-coupled receptor family and plays a crucial role in the regulation of adult stem cell biology.

Function

LGR5 is a receptor for R-spondin family members, which are secreted ligands. The binding of R-spondins to LGR5 enhances Wnt signaling, a pathway that is critical for the control of stem cell self-renewal in various tissues. LGR5 is highly expressed in stem cells of the intestinal epithelium and the hair follicle, where it marks actively dividing stem cells.

Clinical significance

LGR5 has been identified as a potential stem cell marker in the colon and stomach. It is also overexpressed in several types of cancer, including colorectal, ovarian, and basal cell carcinoma. This overexpression is associated with poor prognosis, suggesting that LGR5 may be a potential target for cancer therapy.

Research

Research on LGR5 is ongoing, with studies investigating its role in stem cell biology and its potential as a therapeutic target in cancer. In addition, LGR5 is being studied for its role in tissue regeneration and wound healing.

See also

• G protein-coupled receptor
• R-spondin
• Wnt signaling pathway
• Stem cell

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