LNCaP

From WikiMD's Wellness Encyclopedia

LNCaP
Comparison of cancer cell lines
File:Thalmann figure.png
Thalmann figure

LNCaP (Lymph Node Carcinoma of the Prostate) is a human prostate cancer cell line commonly used in cancer research. It was established from a metastatic lesion of human prostatic adenocarcinoma in the left supraclavicular lymph node of a 50-year-old Caucasian male. LNCaP cells are androgen-sensitive, meaning their growth is stimulated by androgens, which are male hormones such as testosterone.

Characteristics[edit | edit source]

LNCaP cells exhibit several characteristics that make them valuable for research:

Research Applications[edit | edit source]

LNCaP cells are widely used in various areas of prostate cancer research, including:

  • Drug discovery: Testing the efficacy of new therapeutic agents.
  • Gene expression studies: Understanding the role of specific genes in prostate cancer progression.
  • Signal transduction pathways: Investigating how signals are transmitted within cells to promote cancer growth.

Culturing LNCaP Cells[edit | edit source]

LNCaP cells are typically cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin. They are maintained at 37°C in a humidified atmosphere containing 5% carbon dioxide (CO2).

Related Cell Lines[edit | edit source]

Other prostate cancer cell lines used in research include:

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]


Contributors: Prab R. Tumpati, MD