LRP5L

Leucine-rich repeat-containing protein 12
Identifiers
Symbol	?
NCBI gene	9234
HGNC	6690
OMIM	604270
RefSeq	NM_014055
UniProt	Q9Y573
Search for Structures Swiss-model Domains InterPro

Leucine-rich repeat-containing protein 12 (LRP12) is a protein that in humans is encoded by the LRP12 gene. This protein is part of the leucine-rich repeat (LRR) family, which is characterized by the presence of leucine-rich repeat motifs that are involved in protein-protein interactions.

Structure

The LRP12 protein contains multiple leucine-rich repeats, which are short sequence motifs that form a horseshoe-shaped structure. These motifs are typically involved in the formation of protein complexes and are important for the protein's function in cellular signaling pathways.

Function

LRP12 is involved in various cellular processes, including cell adhesion, signal transduction, and possibly in the regulation of gene expression. The exact biological function of LRP12 is still under investigation, but it is believed to play a role in the development and maintenance of tissues.

Clinical Significance

Mutations or dysregulation of the LRP12 gene may be associated with certain diseases, although specific conditions have not been conclusively linked to LRP12. Research is ongoing to determine the potential role of LRP12 in cancer and other diseases.

Research

Studies have shown that LRP12 may interact with other proteins involved in signaling pathways, suggesting a role in modulating cellular responses to external stimuli. Further research is needed to elucidate the precise mechanisms by which LRP12 functions in the cell.

Also see

• Leucine-rich repeat
• Protein-protein interaction
• Signal transduction
• Gene expression