LRRIQ3

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LRRIQ3 is a gene that encodes the protein Leucine-Rich Repeats and IQ Motif Containing 3. This gene is located on chromosome 12 in humans. The protein encoded by LRRIQ3 is involved in various cellular processes, although its specific functions are not fully understood.

Structure

The LRRIQ3 gene is composed of multiple exons and spans a significant portion of chromosome 12. The protein product contains leucine-rich repeats (LRRs) and an IQ motif, which are indicative of its potential role in protein-protein interactions and calcium binding, respectively.

Function

The precise biological function of LRRIQ3 remains to be fully elucidated. However, proteins with leucine-rich repeats are typically involved in the formation of protein complexes and play roles in signal transduction, cell adhesion, and immune response. The IQ motif suggests that LRRIQ3 may interact with calmodulin or other calcium-binding proteins, implicating it in calcium signaling pathways.

Expression

LRRIQ3 is expressed in various tissues, with higher expression levels observed in the brain and reproductive organs. This pattern of expression suggests that LRRIQ3 may have specialized roles in the nervous system and reproductive processes.

Clinical Significance

Mutations or dysregulation of the LRRIQ3 gene may be associated with certain medical conditions, although specific diseases directly linked to LRRIQ3 have not been conclusively identified. Further research is needed to determine the clinical implications of alterations in LRRIQ3 expression or function.

Research

Ongoing studies aim to uncover the detailed mechanisms by which LRRIQ3 contributes to cellular functions and its potential involvement in disease states. Research efforts include the use of model organisms, cell culture systems, and advanced genomic techniques to investigate the role of LRRIQ3 in health and disease.

See also

• Chromosome 12
• Leucine-rich repeat
• IQ motif
• Calcium signaling
• Protein-protein interactions