LRRTM1

Ideogram human chromosome 2

LRRTM1

LRRTM1, also known as Leucine-rich repeat transmembrane neuronal protein 1, is a protein that in humans is encoded by the LRRTM1 gene. LRRTM1 is a member of the LRRTM family of synaptic adhesion molecules. It plays a crucial role in synaptic function and has been implicated in various neurological disorders. Structure LRRTM1 is a transmembrane protein that contains leucine-rich repeats in its extracellular domain. These repeats are involved in protein-protein interactions, particularly in the formation of synaptic connections. LRRTM1 also has a cytoplasmic domain that interacts with intracellular signaling molecules to regulate synaptic transmission. Function LRRTM1 is primarily expressed in the brain, especially in regions involved in synaptic transmission and plasticity. It is known to interact with other synaptic proteins such as neurexins and postsynaptic density proteins, contributing to the formation and maintenance of synapses. LRRTM1 has been shown to play a role in excitatory synaptic transmission and synaptic plasticity. Clinical Relevance Mutations in the LRRTM1 gene have been associated with various neurological disorders, including schizophrenia, autism spectrum disorders, and intellectual disabilities. These mutations can disrupt synaptic function and lead to abnormal brain development and function. Understanding the role of LRRTM1 in these disorders may provide insights into their underlying mechanisms and potential therapeutic targets. Research Research on LRRTM1 continues to uncover its importance in synaptic function and neurological disorders. Studies are investigating the specific interactions of LRRTM1 with other synaptic proteins and signaling pathways. Additionally, research is exploring potential therapeutic strategies targeting LRRTM1 to modulate synaptic function in neurological disorders. References 1. Siddiqui TJ, Craig AM. Synaptic organizing complexes. Curr Opin Neurobiol. 2011 Feb;21(1):132-43. doi: 10.1016/j.conb.2010.08.016. Epub 2010 Sep 21. PMID: 20863767. 2. Soler-Llavina GJ, Arstikaitis P, Morishita W, Ahmad M, Südhof TC, Malenka RC. Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation. Neuron. 2013 Jan 9;79(2):439-46. doi: 10.1016/j.neuron.2013.06.018. PMID: 23889932. Categories: