LY2181308
LY2181308 is an antisense oligonucleotide that complementarily binds to survivin mRNA and inhibits its expression in tumor tissue.[1]
It being investigated for a number of different cancers.[2]
It is targeted at survivin which prevents cells dying.[3]
Clinical trials[edit | edit source]
It has completed a phase II trial for acute myeloid leukemia.[4]
A phase II trial for non-small cell lung cancer has started.[5]
A phase II trial for hormone-refractory prostate cancer will run until early 2012.[6]
References[edit | edit source]
- ↑ , Phase I study of LY2181308, an antisense oligonucleotide against survivin, in patients with advanced solid tumors., Cancer Chemother. Pharmacol., Vol. 68(Issue: 2), pp. 505–11, DOI: 10.1007/s00280-010-1506-7, PMID: 21079959,
- ↑ Search of: LY2181308 Full text, ClinicalTrials.gov,
- ↑ Cancer Full text, Isis Pharmaceuticals, Accessed on: 2019-08-31.
- ↑ A Study of LY2181308 Sodium in Patients With Relapsed or Refractory Acute Myeloid Leukemia Full text, ClinicalTrials.gov,
- ↑ Study of LY2181308 in Combination With Docetaxel Versus Docetaxel in Patients With Non-Small Cell Lung Cancer Full text, ClinicalTrials.gov,
- ↑ A Study of an Experimental Chemotherapy Combination to Treat Hormone Refractory Prostate Cancer Full text, ClinicalTrials.gov,
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