LY503430
LY503430 is a drug that was developed by Eli Lilly for potential use in the treatment of Alzheimer's disease and schizophrenia. It acts as an AMPA receptor positive allosteric modulator, which means it increases the activity of the AMPA receptor.
Pharmacology[edit | edit source]
LY503430 is a potent and selective AMPA receptor positive allosteric modulator. The AMPA receptor is one of the three main types of ionotropic glutamate receptors, the others being NMDA and kainate receptors. AMPA receptors mediate fast synaptic transmission in the central nervous system (CNS).
LY503430 enhances AMPA receptor function by increasing the amplitude of AMPA receptor-mediated currents and by slowing the rate of AMPA receptor desensitization. This results in an increase in synaptic plasticity, which is thought to be beneficial in the treatment of conditions such as Alzheimer's disease and schizophrenia.
Clinical Trials[edit | edit source]
LY503430 has undergone Phase I clinical trials for the treatment of Alzheimer's disease and schizophrenia. However, the results of these trials have not been publicly disclosed, and it is unclear whether the drug will proceed to Phase II trials.
See Also[edit | edit source]
References[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
