Lan blood group system

Lan blood group system is a blood group system that was discovered in 2012. It is named after the first individual in whom the antibody was identified. The Lan blood group system is one of the 36 recognized human blood group systems and is considered to be a very rare blood group.

History

The Lan blood group system was discovered in 2012 when a woman of Polynesian descent was found to have an unusual reaction to a blood transfusion. The woman's blood reacted with all other blood types except for a very rare type, which was later named the Lan blood group. This discovery led to further research and the identification of the ABCB6 gene, which is responsible for the Lan blood group system.

Genetics

The Lan blood group system is controlled by the ABCB6 gene, which is located on chromosome 2. The ABCB6 gene encodes a protein that is a member of the ATP-binding cassette (ABC) transporter superfamily. This protein is involved in the transport of heme from the mitochondria to the cytoplasm, a process that is essential for the production of hemoglobin.

Clinical significance

The Lan blood group system is clinically significant in blood transfusion and pregnancy. Individuals with the rare Lan negative blood type can produce alloantibodies if exposed to Lan positive blood, which can lead to hemolytic disease of the newborn (HDN) or hemolytic transfusion reaction (HTR).

See also

• Blood group system
• ABCB6
• Hemolytic disease of the newborn
• Hemolytic transfusion reaction

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