Large cell acanthoma

Large Cell Acanthoma is a benign skin lesion that typically occurs in elderly individuals. It is characterized by its large, pale-staining keratinocytes, which are significantly larger than the surrounding normal keratinocytes.

History

Large Cell Acanthoma was first described by Robert A. Schwartz and Ronald P. Rapini in 1987. They identified it as a distinct clinical and histopathological entity, separate from other skin disorders.

Clinical Presentation

Large Cell Acanthoma typically presents as a solitary, well-demarcated, pink or brown patch that measures less than 1 cm in diameter. It is most commonly found on sun-exposed areas of the body, such as the face, neck, and arms. The lesion is usually asymptomatic, but it may occasionally cause mild itching or discomfort.

Diagnosis

The diagnosis of Large Cell Acanthoma is primarily based on histopathological examination. The characteristic feature is the presence of large, pale-staining keratinocytes in the epidermis. These cells are significantly larger than the surrounding normal keratinocytes and have a clear perinuclear halo. Other diagnostic methods, such as dermoscopy and immunohistochemistry, may also be used to support the diagnosis.

Treatment

Treatment for Large Cell Acanthoma is usually not necessary, as the lesion is benign and does not cause any significant symptoms. However, if the lesion is bothersome or cosmetically unacceptable, it can be removed by simple surgical excision or cryotherapy.

See Also

• Actinic keratosis
• Seborrheic keratosis
• Solar lentigo