Lateral globus pallidus

General Information
Latin	globus pallidus lateralis
Greek
TA98
TA2
FMA
Details
System	Nervous system
Artery	Anterior choroidal artery
Vein	Internal cerebral veins
Nerve
Lymphatic drainage
Precursor
Function
Identifiers
Clinical significance
Notes

The lateral globus pallidus is a subcomponent of the globus pallidus, which is part of the basal ganglia in the brain. It plays a crucial role in the regulation of voluntary movement.

Structure

The lateral globus pallidus is located within the basal ganglia, a group of nuclei in the brain associated with a variety of functions including motor control, emotions, and cognitive functions. It is situated lateral to the medial globus pallidus and is separated from it by the internal capsule.

Function

The primary function of the lateral globus pallidus is to regulate movements that are initiated by the cerebral cortex. It receives input from the striatum and sends inhibitory signals to the subthalamic nucleus and the thalamus, which in turn modulate the activity of the motor cortex.

Clinical significance

Dysfunction of the lateral globus pallidus is associated with several neurological disorders, including Parkinson's disease and Huntington's disease. In Parkinson's disease, there is excessive inhibitory output from the globus pallidus, leading to the characteristic motor symptoms of the disease. In contrast, in Huntington's disease, there is degeneration of the striatal neurons that project to the globus pallidus, resulting in reduced inhibitory output and hyperkinetic movements.

See also

• Basal ganglia
• Medial globus pallidus
• Subthalamic nucleus
• Thalamus

References

,

 Microcircuitry of the direct and indirect pathways of the basal ganglia, 
 Neuroscience, 
 1998, 
 Vol. 86(Issue: 2), 
 pp. 353–387, 
 DOI: 10.1016/S0306-4522(98)00004-9,

Eric R.,

 Principles of Neural Science, 
  
 McGraw-Hill, 
 2013, 
  
  
 ISBN 978-0071390118,

External links

• Basal ganglia on WikiMD