Leptomeningeal

Leptomeningeal is a term that refers to the two innermost layers of the meninges, the membranes that cover the brain and spinal cord. These layers are the arachnoid mater and the pia mater. The term is often used in the context of diseases that affect these layers, such as leptomeningeal carcinomatosis.

Structure

The leptomeninges consist of two layers: the arachnoid mater and the pia mater. The arachnoid mater is the middle layer of the meninges and is named for its spider web-like appearance. The pia mater is the innermost layer and is in direct contact with the brain and spinal cord. These layers are separated by the subarachnoid space, which is filled with cerebrospinal fluid.

Function

The leptomeninges, along with the other meninges, serve to protect the brain and spinal cord. They provide a barrier against disease and injury, and they help to circulate cerebrospinal fluid.

Clinical significance

Diseases that affect the leptomeninges can have serious consequences. One such disease is leptomeningeal carcinomatosis, a condition in which cancer cells spread to the leptomeninges. This can lead to a variety of symptoms, including headaches, seizures, and neurological deficits. Treatment typically involves chemotherapy or radiation therapy.

Other conditions that can affect the leptomeninges include meningitis, an inflammation of the meninges, and subarachnoid hemorrhage, a type of stroke that occurs when there is bleeding into the subarachnoid space.

See also

• Meninges
• Leptomeningeal carcinomatosis
• Meningitis
• Subarachnoid hemorrhage

References

Leptomeningeal Resources
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