Probucol
(Redirected from Lesterol)
Probucol[edit | edit source]
Probucol is a lipid-lowering agent that was initially developed for the treatment of coronary artery disease. It was originally used to lower cholesterol levels, but its use has declined due to concerns about its side effects and the availability of more effective treatments.
Mechanism of Action[edit | edit source]
Probucol works by increasing the rate of cholesterol excretion from the body. It is thought to act by enhancing the activity of the enzyme cholesterol 7 alpha-hydroxylase, which is involved in the conversion of cholesterol to bile acids. Probucol also has antioxidant properties, which may contribute to its effects on lipid levels.
Clinical Use[edit | edit source]
Probucol was primarily used to treat hyperlipidemia, particularly in patients who did not respond adequately to other lipid-lowering therapies. However, its use has been limited due to its potential to cause QT interval prolongation, which can lead to serious cardiac arrhythmias.
Side Effects[edit | edit source]
The most significant side effect of probucol is its potential to prolong the QT interval on the electrocardiogram, which can increase the risk of torsades de pointes, a type of life-threatening arrhythmia. Other side effects may include gastrointestinal disturbances, such as nausea and diarrhea.
History[edit | edit source]
Probucol was first introduced in the 1970s as a treatment for hypercholesterolemia. Despite its initial promise, its use has declined due to safety concerns and the development of more effective and safer lipid-lowering agents, such as statins.
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