Leukotriene B4 receptor
Leukotriene B4 receptor
The Leukotriene B4 receptor (LTB4 receptor) is a G protein-coupled receptor (GPCR) that binds to leukotriene B4 (LTB4), a potent inflammatory mediator. This receptor plays a crucial role in the immune system by mediating the effects of LTB4, which include the recruitment and activation of leukocytes.
Structure[edit | edit source]
The LTB4 receptor is a member of the G protein-coupled receptor family, characterized by seven transmembrane domains. There are two main subtypes of the LTB4 receptor: BLT1 and BLT2. BLT1 has a high affinity for LTB4, while BLT2 has a lower affinity but can also bind other ligands.
Function[edit | edit source]
The primary function of the LTB4 receptor is to mediate the biological effects of LTB4. Upon binding to LTB4, the receptor activates intracellular signaling pathways that lead to various immune responses, including:
- Chemotaxis: The directed movement of leukocytes towards the site of inflammation.
- Activation of neutrophils and other immune cells.
- Promotion of cytokine and chemokine production.
Role in Disease[edit | edit source]
The LTB4 receptor is implicated in several inflammatory diseases due to its role in leukocyte recruitment and activation. Conditions associated with dysregulated LTB4 receptor activity include:
Pharmacology[edit | edit source]
Given its role in inflammation, the LTB4 receptor is a target for therapeutic intervention. Antagonists of the LTB4 receptor are being investigated for their potential to treat inflammatory diseases by inhibiting the receptor's activity and reducing leukocyte recruitment and activation.
Related Pages[edit | edit source]
Categories[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD