Leukotriene B4 receptor 2
Leukotriene B4 receptor 2[edit | edit source]
The Leukotriene B4 receptor 2, also known as BLT2, is a G protein-coupled receptor that plays a crucial role in the immune response and inflammation. It is a member of the leukotriene receptor family and is primarily expressed in immune cells, such as neutrophils, macrophages, and dendritic cells.
Structure[edit | edit source]
The BLT2 receptor is encoded by the LTB4R2 gene, which is located on chromosome 14 in humans. It consists of 7 transmembrane domains and an extracellular N-terminus. The receptor undergoes conformational changes upon binding to its ligand, leukotriene B4 (LTB4), which activates downstream signaling pathways.
Function[edit | edit source]
The main function of the BLT2 receptor is to mediate the effects of LTB4, a potent lipid mediator involved in the recruitment and activation of immune cells. Upon binding to BLT2, LTB4 triggers a cascade of intracellular events, leading to the activation of various signaling pathways, including the MAPK and PI3K/Akt pathways.
Activation of the BLT2 receptor promotes the migration of immune cells to sites of inflammation, enhances phagocytosis, and stimulates the production of pro-inflammatory cytokines. Additionally, BLT2 has been implicated in the regulation of cell proliferation, angiogenesis, and tissue remodeling.
Clinical Significance[edit | edit source]
Dysregulation of the BLT2 receptor has been associated with several inflammatory diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. Inhibition of BLT2 signaling has shown promise as a therapeutic strategy for these conditions.
See Also[edit | edit source]
References[edit | edit source]
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