Leydig cells

Leydig cells, also known as interstitial cells of Leydig, are cells found adjacent to the seminiferous tubules in the testicle. They produce testosterone in the presence of luteinizing hormone (LH). Leydig cells are polyhedral in shape, display a large prominent nucleus, an eosinophilic cytoplasm and numerous lipid-filled vesicles.

Function

Leydig cells are responsible for the production of testosterone, a steroid hormone essential for male sexual differentiation and development. The production of testosterone is stimulated by luteinizing hormone, which is produced by the pituitary gland.

Development

Leydig cells develop from the mesenchyme cells present in the gonadal ridge. They start to appear in the testes from the 8th week of gestation and increase in number until the 16th week of gestation.

Clinical significance

Abnormalities in Leydig cell function can lead to disorders such as hypogonadism, Klinefelter syndrome, and cryptorchidism. Leydig cell tumors, although rare, can also occur and may produce androgens or estrogens.

See also

• Sertoli cell
• Theca of follicle
• Testosterone

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