Ligase
Ligase is an enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a key role in DNA replication and repair.
Function[edit | edit source]
Ligase is crucial in both DNA replication and DNA repair. In DNA replication, it connects the Okazaki fragments (short DNA sequences) on the lagging strand to complete the newly formed DNA. In DNA repair, it seals the nicks in the DNA structure, restoring the continuity of the DNA strand.
Types[edit | edit source]
There are two main types of ligases – DNA ligase and RNA ligase. DNA ligase is used in both DNA replication and DNA repair. RNA ligase, on the other hand, is used in a few RNA processes, including RNA repair, the resolution of RNA circles, and certain RNA maturation pathways.
Role in Biotechnology[edit | edit source]
Ligase has a significant role in biotechnology, particularly in genetic engineering. It is used in molecular cloning to join DNA fragments together, creating recombinant DNA molecules.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
