Lipoprotein-X
Lipoprotein-X (Lp-X) is an abnormal lipoprotein that is found in the plasma of individuals with obstructive jaundice and certain other liver diseases. It is characterized by a high lipid content and a deficiency of apolipoprotein.
Structure[edit | edit source]
Lipoprotein-X is composed of phospholipids and free cholesterol. It lacks apolipoprotein B, which is normally found in other lipoproteins, and instead contains apolipoprotein E and apolipoprotein A-I.
Function[edit | edit source]
The function of Lipoprotein-X is not fully understood. It is thought to play a role in the transport of cholesterol from the liver to the peripheral tissues. However, its high lipid content and lack of apolipoprotein B may interfere with this process, leading to the accumulation of cholesterol in the liver.
Clinical significance[edit | edit source]
Lipoprotein-X is found in high levels in the plasma of individuals with obstructive jaundice and certain other liver diseases. It is also found in the plasma of individuals with familial lecithin-cholesterol acyltransferase deficiency, a rare genetic disorder that affects the metabolism of lipids.
The presence of Lipoprotein-X in the plasma can lead to a number of clinical manifestations, including xanthomas (yellowish deposits of fat underneath the skin), corneal opacities, and premature atherosclerosis.
See also[edit | edit source]
| Lipoprotein-X Resources | |
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