Lipoprotein-X

Lipoprotein-X (Lp-X) is an abnormal lipoprotein that is found in the plasma of individuals with obstructive jaundice and certain other liver diseases. It is characterized by a high lipid content and a deficiency of apolipoprotein.

Structure

Lipoprotein-X is composed of phospholipids and free cholesterol. It lacks apolipoprotein B, which is normally found in other lipoproteins, and instead contains apolipoprotein E and apolipoprotein A-I.

Function

The function of Lipoprotein-X is not fully understood. It is thought to play a role in the transport of cholesterol from the liver to the peripheral tissues. However, its high lipid content and lack of apolipoprotein B may interfere with this process, leading to the accumulation of cholesterol in the liver.

Clinical significance

Lipoprotein-X is found in high levels in the plasma of individuals with obstructive jaundice and certain other liver diseases. It is also found in the plasma of individuals with familial lecithin-cholesterol acyltransferase deficiency, a rare genetic disorder that affects the metabolism of lipids.

The presence of Lipoprotein-X in the plasma can lead to a number of clinical manifestations, including xanthomas (yellowish deposits of fat underneath the skin), corneal opacities, and premature atherosclerosis.

See also

• Lipoprotein
• Obstructive jaundice
• Liver disease
• Apolipoprotein
• Cholesterol
• Xanthoma
• Atherosclerosis