List of MeSH codes (D08)

List of MeSH codes (D08) refers to a comprehensive categorization within the Medical Subject Headings (MeSH) system, specifically focusing on the section designated as D08, which encompasses enzymes and coenzymes. MeSH is a hierarchical controlled vocabulary used for indexing, cataloging, and searching for biomedical and health-related information. It facilitates the organization of knowledge in these domains to enhance the efficiency of scientific communication. The D08 category is crucial for researchers, healthcare professionals, and students who are involved in various fields of biology, medicine, and pharmacology, as it provides a structured way to access information on enzymes, which are vital for understanding biochemical processes and drug development.

Overview

The D08 category of MeSH codes is subdivided into several subcategories that cover different types of enzymes and coenzymes. These include, but are not limited to, oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases. Each subcategory further drills down into specific enzymes or enzyme families, reflecting the complexity and diversity of enzymatic functions in biological systems.

Subcategories and Examples

Below are some of the subcategories and examples of enzymes within the D08 category of MeSH codes:

• Oxidoreductases (D08.811) - Enzymes that catalyze oxidation-reduction reactions, where the transfer of electrons occurs between two chemical species. Examples include cytochrome P450 enzymes and lactate dehydrogenase.
• Transferases (D08.811.913) - These enzymes transfer a functional group (e.g., a methyl or phosphate group) from one molecule to another. Examples include DNA methyltransferases and kinases.
• Hydrolases (D08.811.277) - Enzymes that catalyze the cleavage of chemical bonds through the addition of water. Examples include proteases, lipases, and esterases.
• Lyases (D08.811.520) - Enzymes that break chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure. Examples include decarboxylases and aldolases.
• Isomerases (D08.811.399) - These enzymes catalyze the rearrangement of atoms within a molecule, changing it into an isomeric form. Examples include racemases and epimerases.
• Ligases (D08.811.464) - Enzymes that catalyze the joining of two molecules with the concomitant hydrolysis of a diphosphate bond in ATP or a similar triphosphate. Examples include DNA ligase and aminoacyl-tRNA synthetases.

Importance

Understanding the functions and mechanisms of enzymes categorized under MeSH codes D08 is fundamental to the fields of biochemistry, molecular biology, pharmacology, and medicine. Enzymes play critical roles in metabolism, gene regulation, signal transduction, and disease pathogenesis. Consequently, they are often targets for therapeutic intervention and drug development. The classification of enzymes into a structured system like MeSH facilitates research, education, and communication across disciplines.

Conclusion

The List of MeSH codes (D08) serves as an essential resource for the scientific and medical communities, providing a systematic approach to the study of enzymes and coenzymes. By categorizing these biomolecules into a coherent framework, MeSH enables more efficient search and retrieval of information, thereby supporting advancements in research, diagnostics, and therapy.

List of MeSH codes (D08) Resources
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