List of polysubstance combinations

List of Polysubstance Combinations

Polysubstance combinations involve the use of more than one psychoactive substance simultaneously or sequentially. These combinations can alter the effects of the individual substances, sometimes leading to enhanced effects, reduced side effects, or unexpected and potentially dangerous interactions. This article provides an overview of some common and notable polysubstance combinations, highlighting their uses, risks, and the rationale behind their combination. It is important to note that the use of polysubstance combinations can significantly increase the risk of adverse effects, including overdose and death.

Common Polysubstance Combinations

Alcohol and Benzodiazepines

Combining alcohol with benzodiazepines is a common but dangerous practice. Both substances are central nervous system depressants, which can lead to enhanced sedative effects but also significantly increase the risk of respiratory depression, coma, and death.

Cannabis and Tobacco

Mixing cannabis with tobacco is popular in many cultures. This combination can modulate the effects of cannabis, potentially reducing anxiety and nausea. However, it also increases the health risks associated with tobacco use, including respiratory issues and cardiovascular disease.

Cocaine and Alcohol

The combination of cocaine and alcohol produces a third substance in the liver called cocaethylene, which has a longer duration of action than cocaine and is more toxic. This combination increases the strain on the heart and can lead to increased risk of heart attacks, strokes, and sudden death.

MDMA and LSD

Combining MDMA (commonly known as ecstasy) with LSD (acid) is known as "candy flipping." This combination is said to merge the intense visual and sensory effects of LSD with the euphoria and empathy generated by MDMA. However, it also increases the risk of dehydration, hyperthermia, and serotonin syndrome.

Opioids and Benzodiazepines

The combination of opioids and benzodiazepines is particularly risky due to the high potential for respiratory depression, leading to overdose and death. Both classes of drugs suppress breathing, and their combined effects can be unpredictable and dangerous.

Risks and Considerations

The use of polysubstance combinations increases the complexity of the drug experience and significantly elevates the risk of negative health outcomes, including overdose. The interactions between different substances can be unpredictable and vary greatly between individuals. It is crucial to understand the potential risks and to approach any substance use with caution.

See Also

• Drug interaction
• Harm reduction
• Psychoactive drug
• Substance abuse

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