Luteinizing hormone-releasing hormone

Luteinizing hormone-releasing hormone

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Luteinizing hormone-releasing hormone (LHRH), also known as gonadotropin-releasing hormone (GnRH), is a tropic hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.

Function

LHRH is synthesized and released from neurons within the hypothalamus. It is a key regulator of the reproductive system, controlling the release of FSH and LH, which in turn regulate the function of the ovaries and testes.

Mechanism of Action

LHRH acts on the pituitary gland by binding to specific receptors on the surface of gonadotrophs, stimulating the synthesis and secretion of FSH and LH. These hormones are crucial for ovulation in females and spermatogenesis in males.

Clinical Significance

LHRH analogs are used in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer. They are also used in assisted reproductive technology to control the timing of ovulation.

See Also

• Hypothalamic–pituitary–gonadal axis
• Endocrinology
• Hormone therapy

External Links

• [LHRH at the US National Library of Medicine Medical Subject Headings (MeSH)](https://www.ncbi.nlm.nih.gov/mesh/68007429)

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