Gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone (GnRH)[edit | edit source]
Gonadotropin-Releasing Hormone (GnRH), also known as luteinizing hormone-releasing hormone (LH-RH), LHRH, and by its chemical name gonadotrophin-releasing hormone, is a pivotal hormone in the regulation of the reproductive system. Produced by the hypothalamus, a part of the brain, GnRH is responsible for signaling the pituitary gland to release two key hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Function and Mechanism[edit | edit source]
GnRH is secreted in a pulsatile fashion, leading to the stimulation of the pituitary gland, which then secretes LH and FSH. These hormones are critical for the development and function of the ovaries in females and the testicles in males. In women, LH and FSH promote ovulation and the production of estrogen and progesterone. In men, they are essential for the production of testosterone and spermatogenesis.
Role in the Body[edit | edit source]
- In Females
GnRH stimulates the pituitary gland to produce LH and FSH, which in turn trigger ovulation and the production of estrogen and progesterone, hormones necessary for the menstrual cycle and pregnancy.
- In Males
The release of GnRH leads to the production of LH and FSH, which stimulate the testicles to produce testosterone and support sperm production.
Clinical Applications[edit | edit source]
GnRH and its analogs have various therapeutic applications in medicine: - Treatment of Hormone-Sensitive Cancers: GnRH analogs can be used to manage prostate cancer in men and endometriosis and breast cancer in women by controlling hormone production. - Fertility Treatments: GnRH agonists and antagonists are used in assisted reproductive technologies (ART) to regulate ovulation. - Management of Precocious Puberty: GnRH analogs can delay the onset of puberty in children with precocious puberty to ensure normal growth and development.
GnRH Analogues[edit | edit source]
GnRH analogues, both agonists and antagonists, are synthetic hormones that mimic or inhibit the natural function of GnRH, used to treat a variety of conditions related to reproductive health.
External Links[edit | edit source]
- Endocrine Society - Gonadotropin-Releasing Hormone
- National Cancer Institute - Gonadotropin-Releasing Hormone
References[edit | edit source]
| Gonadotropin-releasing hormone Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Kondreddy Naveen
