Hypothalamic–pituitary–thyroid axis

Hypothalamic–pituitary–thyroid axis (also known as the HPT axis) is a complex set of direct influences and feedback interactions among three endocrine glands: the hypothalamus, the pituitary gland, and the thyroid gland.

The HPT axis is an integral part of the neuroendocrine system, which controls key processes in the body, including growth, development, metabolism and responses to stress and injury.

Function[edit | edit source]

The HPT axis plays a crucial role in maintaining thyroid homeostasis. This is achieved through a series of hormonal signals and feedback loops. The hypothalamus secretes thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to produce thyroid-stimulating hormone (TSH). TSH, in turn, stimulates the thyroid gland to produce thyroid hormones: thyroxine (T4) and triiodothyronine (T3).

When the levels of T4 and T3 increase in the blood, they inhibit the release of TRH and TSH, thereby reducing their own production. This is an example of a negative feedback loop, which is a common mechanism in the regulation of hormone production.

Disorders[edit | edit source]

Disruptions in the HPT axis can lead to a variety of thyroid disorders, including hyperthyroidism (overactive thyroid), hypothyroidism (underactive thyroid), and thyroiditis (inflammation of the thyroid). These disorders can have a significant impact on a person's health, affecting the body's metabolism, energy levels, and overall well-being.

Treatment[edit | edit source]

Treatment for disorders of the HPT axis typically involves medication to either increase or decrease the production of thyroid hormones. In some cases, surgery may be required to remove part or all of the thyroid gland.