Müllerian

Müllerian refers to the structures in the female that are derived from the embryonic Müllerian ducts. These structures include the fallopian tubes, uterus, the upper part of the vagina, and the cervix. The term is named after the German anatomist Johannes Peter Müller who first described these ducts.

Development

The Müllerian ducts develop in the embryo during the sixth week of gestation. They originate from the mesonephros, which is a part of the intermediate mesoderm. The ducts run down the lateral sides of the urogenital ridge and terminate at the urogenital sinus.

In females, the Müllerian ducts develop into the upper vagina, cervix, uterus, and fallopian tubes. This development is stimulated by the presence of the estrogen hormone. In males, the Müllerian ducts regress due to the presence of Müllerian inhibiting substance (MIS), also known as anti-Müllerian hormone (AMH).

Clinical significance

Abnormalities in the development of the Müllerian ducts can lead to a variety of congenital disorders, including Müllerian agenesis, Müllerian aplasia, and Mayer-Rokitansky-Küster-Hauser syndrome (MRKH). These conditions can result in infertility and other reproductive issues.

See also

• Müllerian duct anomalies
• Müllerian mimicry
• Müllerian regression

References

Müllerian Resources
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