MAOI
| MAFB | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ? | ||||||
| NCBI gene | 9935 | ||||||
| HGNC | 6770 | ||||||
| OMIM | 604439 | ||||||
| RefSeq | NM_005461 | ||||||
| UniProt | O75444 | ||||||
| |||||||
MAFB (v-maf musculoaponeurotic fibrosarcoma oncogene homolog B) is a transcription factor that plays a crucial role in the regulation of gene expression during embryonic development, hematopoiesis, and immune system function. It is a member of the large MAF family of transcription factors, which are characterized by a basic region-leucine zipper (bZIP) domain that facilitates DNA binding and dimerization.
Structure[edit | edit source]
MAFB is a protein encoded by the MAFB gene located on chromosome 20q12. The protein consists of a bZIP domain, which is essential for its function as a transcription factor. This domain allows MAFB to bind to specific DNA sequences and regulate the transcription of target genes.
Function[edit | edit source]
MAFB is involved in various biological processes, including:
- Hematopoiesis: MAFB is critical in the differentiation of monocytes and macrophages. It regulates the expression of genes necessary for the development and function of these immune cells.
- Embryonic development: During development, MAFB is expressed in specific tissues and contributes to the formation of organs such as the kidney and pancreas.
- Immune response: MAFB modulates the immune response by influencing the activity of macrophages and other immune cells.
Clinical Significance[edit | edit source]
Mutations or dysregulation of MAFB have been associated with various diseases, including:
- Diabetes: Altered expression of MAFB in pancreatic beta cells can affect insulin production and secretion, contributing to the development of diabetes.
- Cancer: As an oncogene, MAFB can be involved in the development of certain cancers, particularly those affecting the blood and immune system.
Research[edit | edit source]
Ongoing research is focused on understanding the precise mechanisms by which MAFB regulates gene expression and its role in disease. Studies are also exploring the potential of targeting MAFB in therapeutic strategies for conditions such as cancer and autoimmune diseases.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
