MAP2K3

Ideogram human chromosome 17

MAP2K3

MAP2K3, also known as Mitogen-activated protein kinase kinase 3, is a protein-coding gene that plays a crucial role in the regulation of various cellular processes. It is a member of the MAP kinase kinase family and is involved in the activation of the MAPK signaling pathway.

Function

MAP2K3 functions as a dual-specificity protein kinase, phosphorylating both threonine and tyrosine residues on its substrates. It acts as an intermediary in the MAPK signaling cascade, transmitting signals from upstream MAP kinase kinases to downstream MAP kinases. This signaling pathway is essential for the regulation of cell proliferation, differentiation, and survival.

Structure

The MAP2K3 gene is located on chromosome 17 in humans and encodes a protein with multiple functional domains, including a kinase domain responsible for phosphorylation activity. The protein structure of MAP2K3 is highly conserved across species, highlighting its importance in cellular signaling pathways.

Clinical Significance

Mutations in the MAP2K3 gene have been associated with various diseases, including cancer and inflammatory disorders. Dysregulation of the MAPK signaling pathway, in which MAP2K3 plays a key role, can lead to uncontrolled cell growth and contribute to the development of cancer.

Interactions

MAP2K3 interacts with several other proteins in the MAP kinase pathway, including MAPK1 and MAPK14. These interactions are crucial for the proper transmission of signals within the pathway and ultimately regulate cellular responses to extracellular stimuli.