MAb114
MAb114 is a monoclonal antibody that was developed as a therapeutic treatment for the Ebola virus disease. It was isolated from a survivor of the 1995 Ebola outbreak in Kikwit, Democratic Republic of the Congo. MAb114 binds to the core receptor binding domain of the Ebola virus surface glycoprotein, preventing the virus from entering host cells.
History[edit | edit source]
MAb114 was developed by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). The antibody was isolated from the blood of a survivor of the 1995 Ebola outbreak in Kikwit, Democratic Republic of the Congo. The survivor had a remarkably strong immune response to the virus, which allowed researchers to identify and isolate the effective antibody.
Mechanism of Action[edit | edit source]
MAb114 works by binding to the core receptor binding domain of the Ebola virus surface glycoprotein. This prevents the virus from entering host cells and initiating an infection. The antibody is specific to the Ebola virus and does not affect other viruses.
Clinical Trials and Use[edit | edit source]
MAb114 has been tested in several clinical trials. In a trial conducted in the Democratic Republic of the Congo during an Ebola outbreak in 2018, MAb114 was found to significantly reduce the risk of death from Ebola. It has since been used as a treatment for Ebola in several countries.
Future Research[edit | edit source]
Future research on MAb114 will likely focus on its potential use in preventing Ebola infection, as well as its effectiveness against different strains of the Ebola virus. There is also interest in exploring whether MAb114 could be combined with other treatments to enhance its effectiveness.
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
