MDM2

MDM2 is a gene that encodes a protein that functions as a negative regulator of the p53 tumor suppressor. MDM2 is an important factor in the process of cell cycle regulation and apoptosis.

Function

The protein encoded by the MDM2 gene is a nuclear-localized E3 ubiquitin ligase. It functions to regulate the p53 tumor suppressor, a protein that acts as a transcription factor to regulate cell cycle progression and prevent cancer development. MDM2 does this by binding to p53 and promoting its degradation, thereby controlling the level of p53 in the cell.

Clinical significance

Alterations in the MDM2 gene have been associated with a variety of human cancers. Overexpression of MDM2, due to gene amplification or increased transcription, can lead to decreased levels of p53 and a subsequent increase in cell proliferation and tumor development. In addition, mutations in MDM2 that disrupt its interaction with p53 can also lead to cancer development.

Research

Research into MDM2 has focused on its role in cancer development and progression, as well as its potential as a target for cancer therapy. Several drugs that inhibit the interaction between MDM2 and p53 are currently in clinical trials.

See also

• p53
• Cancer
• Cell cycle
• Apoptosis

References

MDM2 Resources
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