MK-2048

MK-2048 is an antiretroviral drug used in the treatment of HIV/AIDS. It is a second-generation integrase inhibitor, designed to maintain its effectiveness in patients who have developed resistance to the first-generation drugs in this class, such as raltegravir and elvitegravir.

Mechanism of Action

MK-2048 works by inhibiting the action of the HIV enzyme integrase. This enzyme is responsible for integrating the virus's genetic material into the DNA of the infected cell. By blocking this process, MK-2048 prevents the virus from replicating and spreading to other cells.

Clinical Trials

MK-2048 has undergone Phase II clinical trials to evaluate its safety and efficacy in patients with HIV. The results have shown that it is effective in suppressing the virus in patients who have developed resistance to other integrase inhibitors.

Side Effects

The most common side effects of MK-2048 include nausea, headache, and fatigue. In rare cases, it can cause serious side effects such as liver damage and hypersensitivity reactions.

Drug Interactions

MK-2048 can interact with other medications, including other antiretroviral drugs. It is important for patients to inform their healthcare provider of all medications they are currently taking.

Dosage

The recommended dosage of MK-2048 is one tablet taken orally once daily. It can be taken with or without food.

See Also

• Antiretroviral therapy
• HIV/AIDS
• Integrase inhibitors

MK-2048 Resources
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