MK-886
MK-886[edit | edit source]
MK-886 is a chemical compound that acts as a leukotriene biosynthesis inhibitor. It is primarily known for its role in inhibiting the enzyme 5-lipoxygenase-activating protein (FLAP), which is crucial in the biosynthesis of leukotrienes. Leukotrienes are inflammatory mediators that play a significant role in conditions such as asthma and allergic rhinitis.
Mechanism of Action[edit | edit source]
MK-886 functions by binding to FLAP, thereby preventing the conversion of arachidonic acid to leukotriene A4 (LTA4) by the enzyme 5-lipoxygenase. This inhibition reduces the production of downstream leukotrienes, such as leukotriene B4 (LTB4) and the cysteinyl leukotrienes (LTC4, LTD4, and LTE4), which are potent mediators of inflammation and bronchoconstriction.
Clinical Significance[edit | edit source]
The inhibition of leukotriene synthesis by MK-886 has potential therapeutic implications in the treatment of inflammatory diseases. By reducing leukotriene levels, MK-886 may help alleviate symptoms associated with asthma, allergic reactions, and other inflammatory conditions. However, its clinical use is limited, and it is primarily utilized in research settings to study the role of leukotrienes in disease.
Research Applications[edit | edit source]
MK-886 is widely used in pharmacological research to investigate the role of leukotrienes in various diseases. It serves as a tool compound to elucidate the pathways involved in leukotriene-mediated inflammation and to explore potential therapeutic targets for drug development.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
