MMEL1

MMEL1 or Membrane Metallo-Endopeptidase Like 1 is a protein that in humans is encoded by the MMEL1 gene. This protein is a member of the neprilysin (M13) family of zinc metalloendopeptidases.

Function

MMEL1 is a type II transmembrane glycoprotein and is believed to be involved in the regulation of the immune system. It is expressed in various tissues, including the heart, kidney, and nervous system. The exact function of MMEL1 is not fully understood, but it is thought to play a role in the degradation of bioactive peptides, including amyloid beta peptide, which is associated with Alzheimer's disease.

Clinical significance

Mutations in the MMEL1 gene have been associated with various diseases, including cardiovascular disease and neurodegenerative disease. In particular, a variant of the MMEL1 gene has been linked to an increased risk of coronary artery disease.

Research

Research into the function and potential therapeutic applications of MMEL1 is ongoing. It is hoped that a better understanding of this protein could lead to new treatments for diseases such as Alzheimer's and cardiovascular disease.

File:MMEL1 protein structure.jpg

The structure of the MMEL1 protein. Image from Wikimedia Commons.

See also

• Neprilysin
• Alzheimer's disease
• Cardiovascular disease