MT1H

Protein MT1H PDB 1mhu

MT1H

MT1H is a gene that encodes a protein known as Melatonin Receptor 1H. This protein is a member of the G-protein coupled receptor family and is involved in the regulation of circadian rhythms and sleep-wake cycles. The MT1H gene is located on chromosome 4 in humans.

Function

The MT1H protein functions as a receptor for the hormone melatonin. Melatonin is a hormone produced by the pineal gland in response to darkness and plays a key role in regulating the body's internal clock. By binding to melatonin, the MT1H receptor helps to synchronize circadian rhythms and promote sleep.

Clinical Significance

Mutations in the MT1H gene have been associated with sleep disorders and disruptions in circadian rhythms. Individuals with mutations in this gene may experience difficulties with sleep patterns and may be more prone to conditions such as insomnia or delayed sleep phase syndrome.

Interactions

The MT1H receptor interacts with various other proteins and signaling molecules to regulate its function. These interactions play a crucial role in mediating the effects of melatonin on circadian rhythms and sleep.

See also

• Melatonin
• Circadian Rhythms
• Sleep Disorders