MYO18A

Ideogram human chromosome 17

MYO18A

MYO18A is a gene that encodes a protein belonging to the myosin superfamily. This gene is located on chromosome 17 in humans. The protein encoded by MYO18A is involved in various cellular processes, including cell migration, cytoskeletal organization, and intracellular transport.

Structure

MYO18A consists of multiple domains, including an N-terminal motor domain, a coiled-coil region, and a C-terminal tail domain. The motor domain is responsible for the protein's motor activity, which allows it to interact with actin filaments and generate movement within the cell.

Function

The MYO18A protein plays a crucial role in regulating cell migration by facilitating the movement of cellular components along actin filaments. Additionally, MYO18A is involved in maintaining the structural integrity of the cytoskeleton and coordinating intracellular transport processes.

Clinical Significance

Mutations in the MYO18A gene have been associated with certain genetic disorders characterized by abnormal cell migration and cytoskeletal defects. These conditions can lead to developmental abnormalities and various health issues.

Interactions

MYO18A interacts with several other proteins within the cell, forming complexes that are essential for its function. These interactions help regulate the protein's activity and localization within different cellular compartments.