Mannomustine

Mannomustine

Mannomustine is a nitrogen mustard alkylating agent used in chemotherapy. It is a derivative of mechlorethamine and is used in the treatment of various types of cancer, including leukemia, lymphoma, and solid tumors. Mannomustine works by interfering with the cell's DNA and RNA, preventing the cancer cell from growing and dividing.

Mechanism of Action

Mannomustine, like other alkylating agents, works by binding to DNA and causing cross-links between DNA strands. This prevents the DNA from being properly copied during cell division, which in turn prevents the cell from dividing and growing. This is particularly effective against rapidly dividing cells, such as cancer cells.

Uses

Mannomustine is used in the treatment of various types of cancer. It is most commonly used in the treatment of Hodgkin's lymphoma and non-Hodgkin's lymphoma, but it can also be used in the treatment of leukemia, multiple myeloma, and certain types of solid tumors.

Side Effects

Like all chemotherapy drugs, Mannomustine can have serious side effects. These can include nausea, vomiting, hair loss, and bone marrow suppression. Bone marrow suppression can lead to a decrease in the number of white blood cells, red blood cells, and platelets, which can increase the risk of infection, anemia, and bleeding.

History

Mannomustine was first synthesized in the 1950s as part of a series of derivatives of mechlorethamine. It was found to have potent anti-cancer activity and was subsequently developed for use in chemotherapy.

See Also

• Chemotherapy
• Alkylating agent
• Mechlorethamine
• Cancer