Maropitant citrate

Maropitant Citrate is a neurokinin-1 (NK1) receptor antagonist used in veterinary medicine to prevent and treat vomiting and nausea. It is marketed under the brand name Cerenia by Zoetis, and is the first FDA-approved medication for the prevention of vomiting in dogs.

Pharmacology

Maropitant citrate works by blocking the action of substance P, a neurotransmitter in the brain that induces the vomiting reflex. By inhibiting the NK1 receptor, maropitant citrate prevents substance P from binding to the receptor, thereby preventing the signal to vomit.

Uses

Maropitant citrate is used in dogs to prevent acute vomiting and vomiting due to motion sickness. It can also be used to prevent vomiting from chemotherapy in dogs. In cats, it is used to prevent and treat acute vomiting.

Side Effects

Common side effects of maropitant citrate include lethargy, diarrhea, and lack of appetite. In rare cases, it can cause changes in behavior, such as hyperactivity or aggression.

Dosage and Administration

Maropitant citrate is available in tablet form and as an injectable solution. The dosage depends on the weight of the animal and the condition being treated. It is usually given once daily.

Contraindications

Maropitant citrate should not be used in dogs or cats with a known hypersensitivity to the drug. It should also not be used in puppies or kittens less than 16 weeks of age due to the risk of bone marrow hypoplasia.

See Also

• Veterinary Medicine
• Neurokinin-1 Receptor Antagonists
• Substance P

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